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GENETIC CLINIC AND DNA TESTING LAB-2

Rare Disease Forum by Genetidoc Genetic Clinic › Forums › Frequently Asked Questions › Can a “variant of uncertain significance” ever be reclassified later?

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    • August 11, 2026 at 8:04 am #483
      Anonymous
      Moderator

      Can a “variant of uncertain significance” ever be reclassified later?

    • August 11, 2026 at 8:19 am #499
      Genetic Counselor
      Keymaster

      Yes. As research grows and more data becomes available, a variant initially labeled uncertain may later be reclassified as either disease-causing or harmless. Some clinics offer to re-contact patients if a reclassification affects their result.

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