Does PGT-A improve IVF success rates for women over 37 years?

[Anonymous]

Does Preimplantation Genetic Testing for Aneuploidy improve In Vitro Fertilization success rates for women over 37 years?

[Sana Fathima K S]

Yes, with an important clarification on what “success” means. In women over 37 years, the proportion of chromosomally abnormal embryos rises steeply, often exceeding 60–70% of blastocysts formed. For this age group, current evidence shows Preimplantation Genetic Testing for Aneuploidy:

*Improves success per embryo transfer: Transferring a chromosomally normal (euploid) embryo yields significantly higher implantation and live birth rates per transfer compared to an untested embryo of similar grade, since the largest single cause of failure in this age group has been screened out.
*Reduces miscarriage rates: Since a majority of miscarriages in this age group are chromosomal in origin, transferring euploid embryos meaningfully lowers pregnancy loss rates.
*Shortens time to a successful pregnancy: By avoiding transfers of embryos destined to fail or miscarry, couples often reach a live birth in fewer transfer attempts.
*Does not increase the cumulative live birth rate per egg retrieval cycle: Preimplantation Genetic Testing for Aneuploidy does not create more euploid embryos, it identifies which existing embryos are euploid. If a woman over 37 years produces very few or no euploid embryos in a cycle, testing does not change that underlying biological reality.
for women over 37 years, Preimplantation Genetic Testing for Aneuploidy is most valuable for improving the efficiency and predictability of each transfer, not for increasing the total number of embryos available.

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