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Rare Disease Forum by Genetidoc Genetic Clinic Forums Cancer Genetics Hereditary Cancer Syndromes Lynch syndrome Who should consider genetic testing for Lynch syndrome?

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    • #276
      Anonymous
      Moderator

      Who should consider genetic testing for Lynch syndrome?

    • #280
      Sana Fathima K S
      Keymaster

      *Those diagnosed colorectal or endometrial cancer before age 50.
      *Those who had more than one Lynch-related cancer (Cancers in colon, uterine, ovarian, stomach, urinary tract, or small bowel).
      *Multiple family members across generations have had cancers related to Lynch Syndrome.
      *A close relative was diagnosed with colorectal or endometrial cancer before age 50, even if you yourself have not had cancer.
      *A first-degree relative (parent, sibling, or child) has already tested positive for Lynch syndrome.
      *Tumour testing findings indicates genetic causes, findings showed microsatellite instability (MSI-H) or abnormal mismatch repair (MMR) protein results on immunohistochemistry — this is often done automatically on colorectal or endometrial tumors and can prompt a referral for genetic testing.
      *You have a personal or family history of multiple colon polyps, particularly if diagnosed at a younger age.
      *Your family history meets formal clinical criteria used by doctors to flag hereditary cancer risk.

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